Glomerular density and progression
نویسندگان
چکیده
منابع مشابه
Low glomerular density is a risk factor for progression in idiopathic membranous nephropathy.
BACKGROUND The adverse histological features predicting a progressive loss of renal function in idiopathic membranous nephropathy (IMN), before the establishment of impaired renal function with advanced glomerulosclerosis and/or interstitial fibrosis, are still poorly understood. The present study examined the relationship between the glomerular density (GD; non-sclerotic glomerular number/rena...
متن کاملGlomerular pathology and the progression of chronic kidney disease.
Structural studies of the glomerulus, largely undertaken in animal models, have informed our understanding of the progression of chronic kidney disease (CKD) for decades. A fundamental tenet of that understanding is that a loss of podocytes underlies progression in many or most cases of progressive CKD. Recent attempts have been made to reconcile earlier findings from glomerular physiology (the...
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OBJECTIVE To describe the prevalence and determinants of hyperfiltration (glomerular filtration rate [GFR] ≥120 mL/min/1.73 m(2)), GFR decline, and nephropathy onset or progression in type 2 diabetic patients with normo- or microalbuminuria. RESEARCH DESIGN AND METHODS We longitudinally studied 600 hypertensive type 2 diabetic patients with albuminuria <200 μg/min and who were retrieved from ...
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Progressive loss of kidney function consequent to relentless scarring of renal parenchyma is a dreaded consequence of many forms of renal disease, ultimately lead to death, dialysis or transplantation, unless progression can be forestalled. However, in many diseases, including IgA nephropathy and membranous nephropathy only a subset of patients will demonstrate such progressive kidney injury. I...
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Although glomerular immunoglobulin M (IgM) deposition occurs in a variety of glomerular diseases, the mechanism of deposition and its clinical significance remain controversial. Some have theorized IgM becomes passively trapped in areas of glomerulosclerosis. However, recent studies found that IgM specifically binds damaged glomeruli. Therefore, we tested whether natural IgM binds to neo-epitop...
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ژورنال
عنوان ژورنال: Nephrology Dialysis Transplantation
سال: 2012
ISSN: 0931-0509,1460-2385
DOI: 10.1093/ndt/gfs009